Painkillers cause kidney damage

Some painkillers can cause kidney damage, especially when used for a long time or in high doses. This can lead to acute kidney injury (AKI) or chronic kidney disease (CKD). Understanding the types of painkillers and their effects on the kidneys is important to minimize the risk of damage.

Types of painkillers and their effects on the kidneys:

1.Non-steroidal anti-inflammatory Drugs (NSAIDs):

• Examples: Ibuprofen (Advil, motrin), naproxen (Aleb), aspirin.
• Effects: NSAIDs inhibit inflammation and pain by inhibiting enzymes involved in the production of prostaglandins (COX-1 and COX-2), a chemical that promotes inflammation, pain and fever.However, prostaglandins also play a role in maintaining blood flow to the kidneys. Long-term or high-dose use of NSAIDs can reduce blood flow to the kidneys and cause kidney damage or damage.
• Risk Factors: People at high risk of pre-existing kidney disorders, heart failure, liver disease, or being elderly.

2.Acetaminophen (paracetamol):

• Example: Tylenol.
• Effects: Acetaminophen is generally considered safer for the kidneys compared to NSAIDs. However, excessive use can lead to kidney damage, especially when combined with other nephrotoxic drugs or in the case of an overdose.
• Risk Factors: Chronic use or overdose can lead to acute kidney injury. It has low nephrotoxicity compared to NSAIDs, but can cause risks if used incorrectly.

3.Prescription painkillers (opioids):

• Examples: Morphine, oxycodone (oxycontin), hydrocodone (vicodin).
• Effects: Opioids are not directly nephrotoxic, but they can cause urinary retention and other complications that indirectly affect kidney function. In addition, they can lead to changes in blood pressure that can affect kidney health. Oct.
• Risk Factors: The main risks are due to misuse, addiction and the possibility of combining them with other nephrotoxic drugs.

The mechanism of kidney damage:

• Reduced blood flow: NSAIDs can reduce the production of prostaglandins, causing reduced blood flow to the kidneys, potentially causing acute kidney injury.
• Interstitial nephritis: The use of chronic painkillers can cause interstitial nephritis, inflammation of the interstitial tissue of the kidneys, long-term damage and decreased kidney function.
• Direct toxicity: Some painkillers can have a direct toxic effect on kidney cells, especially when taken in large quantities or in combination with other medications.

Prevention and management:

1.Use painkillers sparingly:

• Use the lowest effective dose for the shortest time needed to manage pain.
• Avoid using NSAIDs regularly if they are not prescribed by a healthcare provider.

2.Monitor kidney function:

• If you are taking long-term analgesics, check your kidney function regularly with blood tests (such as serum creatinine) or urine tests.

3.Stay hydrated:

• It maintains kidney function and provides adequate hydration to help support the excretion of waste products.

4.Avoid combinations:

• Be careful to use more than one nephrotoxic medication at the same time, as this may increase the risk of kidney damage.

5.Consult a health professional:

• Be sure to consult with your healthcare provider before starting or stopping the medication, especially if you have underlying health conditions that may affect kidney function.

Result:

Painkillers are effective at managing pain, but they should be used with caution to prevent potential kidney damage. Understanding the risks associated with NSAIDs, acetaminophen, and opioids can help you make informed decisions about pain management. Regular monitoring and consultation with your healthcare professional is essential to minimize the risk and protect kidney health.